210736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3602643..3603057 Replicon chromosome
Accession NZ_CP080091
Organism Salmonella enterica strain SLR1_8245

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag KZY40_RS17645 Protein ID WP_000994230.1
Coordinates 3602800..3603057 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3602643..3602975 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY40_RS17605 3597904..3598401 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
KZY40_RS17610 3599164..3599734 - 571 Protein_3462 integrase core domain-containing protein -
KZY40_RS17615 3599655..3599864 - 210 WP_001676010.1 hypothetical protein -
KZY40_RS17620 3599917..3600231 + 315 WP_072100769.1 SymE family type I addiction module toxin -
KZY40_RS17625 3600298..3600576 - 279 WP_012543321.1 hypothetical protein -
KZY40_RS17630 3600893..3601360 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
KZY40_RS17635 3601357..3601674 - 318 WP_001751277.1 hypothetical protein -
KZY40_RS17640 3602232..3602465 - 234 WP_124084119.1 hypothetical protein -
- 3602643..3602975 - 333 - - Antitoxin
KZY40_RS17645 3602800..3603057 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
KZY40_RS17650 3603123..3603569 - 447 WP_000171102.1 hypothetical protein -
KZY40_RS17655 3603566..3606940 - 3375 Protein_3471 RHS domain-containing protein -
KZY40_RS17660 3606940..3607446 - 507 Protein_3472 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3592335..3606862 14527
flank IS/Tn - - 3599164..3599442 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T210736 WP_000994230.1 NZ_CP080091:3602800-3603057 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T210736 NZ_CP104603:4010754-4010972 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 333 bp

>AT210736 NZ_CP080091:c3602975-3602643 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References