239684

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3696823..3697255 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag MQF88_RS18480 Protein ID WP_000994224.1
Coordinates 3696980..3697255 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3696823..3697245 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS18450 3693041..3693778 - 738 WP_001535430.1 pili assembly chaperone SafB -
MQF88_RS18455 3693862..3694374 - 513 WP_077248260.1 pilus assembly protein -
MQF88_RS18460 3695124..3695828 - 705 Protein_3614 integrase core domain-containing protein -
MQF88_RS18465 3695881..3696129 + 249 WP_001738030.1 SymE family type I addiction module toxin -
MQF88_RS18470 3696231..3696539 - 309 WP_010988969.1 hypothetical protein -
MQF88_RS18475 3696622..3696738 - 117 WP_227457392.1 hypothetical protein -
- 3696823..3697245 - 423 - - Antitoxin
MQF88_RS18480 3696980..3697255 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
MQF88_RS18485 3697308..3697745 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
MQF88_RS18490 3698308..3698754 - 447 WP_000935097.1 protein SciX -
MQF88_RS18495 3698748..3699617 - 870 Protein_3621 polymorphic toxin type 47 domain-containing protein -
MQF88_RS18500 3699681..3699944 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3688295..3699944 11649
flank IS/Tn - - 3695124..3695405 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T239684 WP_000994224.1 NZ_CP094332:3696980-3697255 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T239684 NZ_LS483303:632333-632647 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 423 bp

>AT239684 NZ_CP094332:c3697245-3696823 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References