Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 4363976..4364408 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NMU33_RS21675 Protein ID WP_000994224.1
Coordinates 4364133..4364408 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 4363976..4364398 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS21645 4360194..4360931 - 738 WP_001535430.1 pili assembly chaperone SafB -
NMU33_RS21650 4361015..4361527 - 513 WP_077248260.1 pilus assembly protein -
NMU33_RS21655 4362277..4362981 - 705 Protein_4231 integrase core domain-containing protein -
NMU33_RS21660 4363034..4363282 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NMU33_RS21665 4363384..4363692 - 309 WP_010988969.1 hypothetical protein -
NMU33_RS21670 4363775..4363948 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 4363976..4364398 - 423 - - Antitoxin
NMU33_RS21675 4364133..4364408 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NMU33_RS21680 4364461..4364898 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NMU33_RS21685 4365461..4365907 - 447 WP_000935097.1 protein SciX -
NMU33_RS21690 4365901..4366770 - 870 Protein_4238 polymorphic toxin type 47 domain-containing protein -
NMU33_RS21695 4366834..4367097 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4353124..4367097 13973
flank IS/Tn - - 4362277..4362558 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T252002 WP_000994224.1 NZ_CP101375:4364133-4364408 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT252002 NZ_CP101375:c4364398-4363976 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References