221474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3171926..3172340 Replicon chromosome
Accession NZ_CP085798
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latias

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF55_RS15750 Protein ID WP_000994230.1
Coordinates 3172083..3172340 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3171926..3172258 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF55_RS15710 3167187..3167684 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF55_RS15715 3168447..3169017 - 571 Protein_3068 integrase core domain-containing protein -
LJF55_RS15720 3168938..3169147 - 210 WP_001676010.1 hypothetical protein -
LJF55_RS15725 3169200..3169514 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF55_RS15730 3169581..3169859 - 279 WP_012543321.1 hypothetical protein -
LJF55_RS15735 3170176..3170643 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF55_RS15740 3170640..3170957 - 318 WP_001751277.1 hypothetical protein -
LJF55_RS15745 3171515..3171748 - 234 WP_124084119.1 hypothetical protein -
- 3171926..3172258 - 333 - - Antitoxin
LJF55_RS15750 3172083..3172340 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF55_RS15755 3172406..3172852 - 447 WP_000171102.1 hypothetical protein -
LJF55_RS15760 3172849..3176223 - 3375 Protein_3077 RHS domain-containing protein -
LJF55_RS15765 3176223..3176729 - 507 Protein_3078 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3159291..3176145 16854
flank IS/Tn - - 3168447..3168725 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221474 WP_000994230.1 NZ_CP085798:3172083-3172340 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221474 NZ_CP117398:365573-365848 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 333 bp

>AT221474 NZ_CP085798:c3172258-3171926 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References