Detailed information of TA system TA170653

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 658105..658519
• Replicon: chromosome
• Accession: NZ_CP060674
• Organism: Salmonella enterica strain 190729_4

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: H9Q84_RS03020
• Protein ID: WP_000994230.1
• Coordinates: 658105..658362 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	658187..658519 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q84_RS03005	653716..654222	+	507	Protein_585	phage late control D family protein	-
H9Q84_RS03010	654222..657596	+	3375	Protein_586	RHS domain-containing protein	-
H9Q84_RS03015	657593..658039	+	447	WP_000171102.1	hypothetical protein	-
H9Q84_RS03020	658105..658362	-	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
-	658187..658519	+	333	-	-	Antitoxin
H9Q84_RS03025	658697..658930	+	234	WP_124084119.1	hypothetical protein	-
H9Q84_RS03030	659488..659805	+	318	WP_001751277.1	hypothetical protein	-
H9Q84_RS03035	659802..660269	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
H9Q84_RS03040	660586..660864	+	279	WP_012543321.1	hypothetical protein	-
H9Q84_RS03045	660931..661245	-	315	WP_072100769.1	SymE family type I addiction module toxin	-
H9Q84_RS03050	661298..661507	+	210	WP_001676010.1	hypothetical protein	-
H9Q84_RS03055	661428..661998	+	571	Protein_595	integrase core domain-containing protein	-
H9Q84_RS03060	662761..663258	+	498	WP_016695185.1	Saf-pilin pilus formation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	652801..671892	19091
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 IS/Tn TA010105 341179..341460 0.009 View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA010103 340656..340937 0.009 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026042 341863..342144 0.009	flank	IS/Tn	-	-	661720..661998	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T170653 WP_000994230.1 NZ_CP060674:c658362-658105 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T170653 NZ_CP077668:3805928-3806203 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT170653 NZ_CP060674:658187-658519 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin