Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3547602..3548034 Replicon chromosome
Accession NZ_CP047535
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN08_RS17690 Protein ID WP_000994224.1
Coordinates 3547759..3548034 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3547602..3548024 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN08_RS17660 3543820..3544557 - 738 WP_001535430.1 pili assembly chaperone SafB -
DXN08_RS17665 3544641..3545153 - 513 WP_077248260.1 pilus assembly protein -
DXN08_RS17670 3545903..3546607 - 705 Protein_3458 integrase core domain-containing protein -
DXN08_RS17675 3546660..3546908 + 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN08_RS17680 3547010..3547318 - 309 WP_010988969.1 hypothetical protein -
DXN08_RS17685 3547401..3547574 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3547602..3548024 - 423 - - Antitoxin
DXN08_RS17690 3547759..3548034 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
DXN08_RS17695 3548087..3548524 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN08_RS17700 3549087..3549533 - 447 WP_000935097.1 protein SciX -
DXN08_RS17705 3549527..3550396 - 870 Protein_3465 polymorphic toxin type 47 domain-containing protein -
DXN08_RS17710 3550460..3550723 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3536750..3550723 13973
flank IS/Tn - - 3545903..3546184 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146473 WP_000994224.1 NZ_CP047535:3547759-3548034 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146473 NZ_CP062752:c4697455-4697141 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 423 bp

>AT146473 NZ_CP047535:c3548024-3547602 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References