221596

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1026887..1027301 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF50_RS04785 Protein ID WP_000994230.1
Coordinates 1026887..1027144 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1026969..1027301 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS04770 1022498..1023004 + 507 Protein_909 phage late control D family protein -
LJF50_RS04775 1023004..1026378 + 3375 Protein_910 RHS domain-containing protein -
LJF50_RS04780 1026375..1026821 + 447 WP_000171102.1 hypothetical protein -
LJF50_RS04785 1026887..1027144 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 1026969..1027301 + 333 - - Antitoxin
LJF50_RS04790 1027479..1027712 + 234 WP_124084119.1 hypothetical protein -
LJF50_RS04795 1028270..1028587 + 318 WP_001751277.1 hypothetical protein -
LJF50_RS04800 1028584..1029051 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF50_RS04805 1029368..1029646 + 279 WP_012543321.1 hypothetical protein -
LJF50_RS04810 1029713..1030027 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF50_RS04815 1030080..1030289 + 210 WP_001676010.1 hypothetical protein -
LJF50_RS04820 1030210..1030780 + 571 Protein_919 integrase core domain-containing protein -
LJF50_RS04825 1031543..1032040 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1021583..1040674 19091
flank IS/Tn - - 1030502..1030780 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221596 WP_000994230.1 NZ_CP085803:c1027144-1026887 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221596 NZ_CP117525:227420-227677 [Fusobacterium nucleatum]
ATGTTATTGACTTGGACTGATTTTGCATGGGAACAATATGAAGAATTACAGGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATACCCTTATTAAGGATATAAAAAGGAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAGCTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTTTATAAGATATCAGATAGTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin


Download         Length: 333 bp

>AT221596 NZ_CP085803:1026969-1027301 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References