221864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2436621..2437035 Replicon chromosome
Accession NZ_CP085815
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF37_RS12160 Protein ID WP_000994230.1
Coordinates 2436778..2437035 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2436621..2436953 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF37_RS12120 2431882..2432379 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF37_RS12125 2433142..2433712 - 571 Protein_2372 integrase core domain-containing protein -
LJF37_RS12130 2433633..2433842 - 210 WP_001676010.1 hypothetical protein -
LJF37_RS12135 2433895..2434209 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF37_RS12140 2434276..2434554 - 279 WP_012543321.1 hypothetical protein -
LJF37_RS12145 2434871..2435338 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF37_RS12150 2435335..2435652 - 318 WP_001751277.1 hypothetical protein -
LJF37_RS12155 2436210..2436443 - 234 WP_124084119.1 hypothetical protein -
- 2436621..2436953 - 333 - - Antitoxin
LJF37_RS12160 2436778..2437035 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF37_RS12165 2437101..2437547 - 447 WP_000171102.1 hypothetical protein -
LJF37_RS12170 2437544..2440918 - 3375 Protein_2381 RHS domain-containing protein -
LJF37_RS12175 2440918..2441424 - 507 Protein_2382 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2423986..2440840 16854
flank IS/Tn - - 2433142..2433420 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221864 WP_000994230.1 NZ_CP085815:2436778-2437035 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221864 NZ_CP117609:2316583-2316861 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTAATTGATGCCGCAAGCAGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 333 bp

>AT221864 NZ_CP085815:c2436953-2436621 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References