Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 3724639..3725071 | Replicon | chromosome |
| Accession | NZ_OU015342 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00007171 isolate AUSMDU00007171 | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | E8XIW0 |
| Locus tag | KKQ83_RS18345 | Protein ID | WP_000994224.1 |
| Coordinates | 3724796..3725071 (+) | Length | 92 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 3724639..3725061 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKQ83_RS18315 | 3720857..3721594 | - | 738 | WP_001535430.1 | pili assembly chaperone SafB | - |
| KKQ83_RS18320 | 3721678..3722190 | - | 513 | WP_077248260.1 | pilus assembly protein | - |
| KKQ83_RS18325 | 3722940..3723644 | - | 705 | Protein_3609 | integrase core domain-containing protein | - |
| KKQ83_RS18330 | 3723697..3723945 | + | 249 | WP_001738030.1 | SymE family type I addiction module toxin | - |
| KKQ83_RS18335 | 3724047..3724355 | - | 309 | WP_010988969.1 | hypothetical protein | - |
| KKQ83_RS24625 | 3724438..3724554 | - | 117 | WP_227457392.1 | hypothetical protein | - |
| - | 3724639..3725061 | - | 423 | - | - | Antitoxin |
| KKQ83_RS18345 | 3724796..3725071 | + | 276 | WP_000994224.1 | SymE family type I addiction module toxin | Toxin |
| KKQ83_RS18350 | 3725124..3725561 | - | 438 | WP_000943619.1 | immunity 26/phosphotriesterase HocA family protein | - |
| KKQ83_RS18355 | 3726124..3726570 | - | 447 | WP_000935097.1 | protein SciX | - |
| KKQ83_RS18360 | 3726564..3727433 | - | 870 | Protein_3616 | polymorphic toxin type 47 domain-containing protein | - |
| KKQ83_RS18365 | 3727497..3727760 | - | 264 | WP_000932531.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 3713787..3727760 | 13973 | ||
| flank | IS/Tn | - | - | 3722940..3723221 | 281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10032.36 Da Isoelectric Point: 6.4704
>T294666 WP_000994224.1 NZ_OU015342:3724796-3725071 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
Download Length: 276 bp
Antitoxin
Download Length: 423 bp
>AT294666 NZ_OU015342:c3725061-3724639 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
