263401

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3701915..3702347 Replicon chromosome
Accession NZ_CP110198
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-75

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag OCK70_RS18220 Protein ID WP_000994224.1
Coordinates 3702072..3702347 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3701915..3702337 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK70_RS18190 3698133..3698870 - 738 WP_001535430.1 pili assembly chaperone SafB -
OCK70_RS18195 3698954..3699466 - 513 WP_077248260.1 pilus assembly protein -
OCK70_RS18200 3700216..3700920 - 705 Protein_3560 integrase core domain-containing protein -
OCK70_RS18205 3700973..3701221 + 249 WP_001738030.1 SymE family type I addiction module toxin -
OCK70_RS18210 3701323..3701631 - 309 WP_010988969.1 hypothetical protein -
OCK70_RS18215 3701714..3701830 - 117 WP_227457392.1 hypothetical protein -
- 3701915..3702337 - 423 - - Antitoxin
OCK70_RS18220 3702072..3702347 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
OCK70_RS18225 3702400..3702837 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
OCK70_RS18230 3703400..3703846 - 447 WP_000935097.1 protein SciX -
OCK70_RS18235 3703840..3704709 - 870 Protein_3567 polymorphic toxin type 47 domain-containing protein -
OCK70_RS18240 3704773..3705036 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3691063..3705036 13973
flank IS/Tn - - 3700216..3700497 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T263401 WP_000994224.1 NZ_CP110198:3702072-3702347 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT263401 NZ_CP110198:c3702337-3701915 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References