270660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736452..3736866 Replicon chromosome
Accession NZ_CP117343
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM105

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQP76_RS18595 Protein ID WP_000994230.1
Coordinates 3736609..3736866 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736452..3736784 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP76_RS18555 3731713..3732165 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQP76_RS18560 3732974..3733544 - 571 Protein_3636 integrase core domain-containing protein -
PQP76_RS18565 3733465..3733674 - 210 WP_001676010.1 hypothetical protein -
PQP76_RS18570 3733727..3734041 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQP76_RS18575 3734108..3734386 - 279 WP_012543321.1 hypothetical protein -
PQP76_RS18580 3734702..3735169 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQP76_RS18585 3735166..3735483 - 318 WP_001751277.1 hypothetical protein -
PQP76_RS18590 3736041..3736274 - 234 WP_124084119.1 hypothetical protein -
- 3736452..3736784 - 333 - - Antitoxin
PQP76_RS18595 3736609..3736866 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQP76_RS18600 3736932..3737378 - 447 WP_000171102.1 hypothetical protein -
PQP76_RS18605 3737375..3740197 - 2823 Protein_3645 RHS repeat-associated core domain-containing protein -
PQP76_RS18610 3740245..3740454 + 210 WP_001675680.1 SymE family type I addiction module toxin -
PQP76_RS18615 3740572..3740910 - 339 WP_000201550.1 hypothetical protein -
PQP76_RS18620 3740932..3741252 - 321 WP_016695071.1 HNH endonuclease -
PQP76_RS18625 3741310..3741593 - 284 Protein_3649 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3723818..3742146 18328
flank IS/Tn - - 3732974..3733252 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270660 WP_000994230.1 NZ_CP117343:3736609-3736866 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270660 NZ_CP117343:c3736784-3736452 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References