212685

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3660950..3661382 Replicon chromosome
Accession NZ_CP081189
Organism Salmonella enterica strain sg1722-2

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K4F90_RS17970 Protein ID WP_000994224.1
Coordinates 3661107..3661382 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3660950..3661372 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F90_RS17940 3657169..3657906 - 738 WP_001535430.1 pili assembly chaperone SafB -
K4F90_RS17945 3657990..3658502 - 513 WP_077248260.1 pilus assembly protein -
K4F90_RS17950 3659251..3659955 - 705 Protein_3516 integrase core domain-containing protein -
K4F90_RS17955 3660008..3660256 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K4F90_RS17960 3660358..3660666 - 309 WP_010988969.1 hypothetical protein -
K4F90_RS17965 3660749..3660865 - 117 WP_227457392.1 hypothetical protein -
- 3660950..3661372 - 423 - - Antitoxin
K4F90_RS17970 3661107..3661382 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K4F90_RS17975 3661435..3661872 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K4F90_RS17980 3662435..3662881 - 447 WP_000935097.1 protein SciX -
K4F90_RS17985 3662875..3663744 - 870 Protein_3523 polymorphic toxin type 47 domain-containing protein -
K4F90_RS17990 3663808..3664071 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3650099..3664071 13972
flank IS/Tn - - 3659251..3659532 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T212685 WP_000994224.1 NZ_CP081189:3661107-3661382 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T212685 NZ_CP107321:18105-18575 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 423 bp

>AT212685 NZ_CP081189:c3661372-3660950 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References