170593

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 325192..325606 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag H9Q86_RS01425 Protein ID WP_000994230.1
Coordinates 325192..325449 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 325274..325606 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS01410 320803..321309 + 507 Protein_274 phage late control D family protein -
H9Q86_RS01415 321309..324683 + 3375 Protein_275 RHS domain-containing protein -
H9Q86_RS01420 324680..325126 + 447 WP_000171102.1 hypothetical protein -
H9Q86_RS01425 325192..325449 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 325274..325606 + 333 - - Antitoxin
H9Q86_RS01430 325784..326017 + 234 WP_124084119.1 hypothetical protein -
H9Q86_RS01435 326575..326892 + 318 WP_001751277.1 hypothetical protein -
H9Q86_RS01440 326889..327356 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
H9Q86_RS01445 327673..327951 + 279 WP_012543321.1 hypothetical protein -
H9Q86_RS01450 328018..328332 - 315 WP_072100769.1 SymE family type I addiction module toxin -
H9Q86_RS01455 328385..328594 + 210 WP_001676010.1 hypothetical protein -
H9Q86_RS01460 328515..329085 + 571 Protein_284 integrase core domain-containing protein -
H9Q86_RS01465 329848..330345 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 324680..338979 14299
flank IS/Tn - - 328807..329085 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T170593 WP_000994230.1 NZ_CP060670:c325449-325192 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T170593 NZ_CP077649:3387177-3387584 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 333 bp

>AT170593 NZ_CP060670:325274-325606 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References