146387

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1233633..1234065 Replicon chromosome
Accession NZ_CP047527
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN11_RS05760 Protein ID WP_000994224.1
Coordinates 1233633..1233908 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1233643..1234065 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN11_RS05740 1230944..1231207 + 264 WP_000932531.1 hypothetical protein -
DXN11_RS05745 1231271..1232140 + 870 Protein_1105 polymorphic toxin type 47 domain-containing protein -
DXN11_RS05750 1232134..1232580 + 447 WP_000935097.1 protein SciX -
DXN11_RS05755 1233143..1233580 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN11_RS05760 1233633..1233908 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 1233643..1234065 + 423 - - Antitoxin
DXN11_RS05765 1234150..1234266 + 117 WP_227457392.1 hypothetical protein -
DXN11_RS05770 1234349..1234657 + 309 WP_010988969.1 hypothetical protein -
DXN11_RS05775 1234759..1235007 - 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN11_RS05780 1235060..1235764 + 705 Protein_1112 integrase core domain-containing protein -
DXN11_RS05785 1236514..1237026 + 513 WP_077248260.1 pilus assembly protein -
DXN11_RS05790 1237110..1237847 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1231367..1245655 14288
flank IS/Tn - - 1235483..1235764 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146387 WP_000994224.1 NZ_CP047527:c1233908-1233633 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146387 NZ_CP062744:c5056438-5056265 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 423 bp

>AT146387 NZ_CP047527:1233643-1234065 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References