270618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3713130..3713562 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQP94_RS18460 Protein ID WP_000994224.1
Coordinates 3713287..3713562 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3713130..3713552 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS18430 3709348..3710085 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQP94_RS18435 3710169..3710681 - 513 WP_077946652.1 pilus assembly protein -
PQP94_RS18440 3711431..3712135 - 705 Protein_3607 integrase core domain-containing protein -
PQP94_RS18445 3712188..3712436 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQP94_RS18450 3712538..3712846 - 309 WP_010988969.1 hypothetical protein -
PQP94_RS18455 3712929..3713045 - 117 WP_227457392.1 hypothetical protein -
- 3713130..3713552 - 423 - - Antitoxin
PQP94_RS18460 3713287..3713562 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQP94_RS18465 3713615..3714051 - 437 Protein_3612 immunity 26/phosphotriesterase HocA family protein -
PQP94_RS18470 3714614..3715060 - 447 WP_000935097.1 protein SciX -
PQP94_RS18475 3715054..3715922 - 869 Protein_3614 polymorphic toxin type 47 domain-containing protein -
PQP94_RS18480 3715986..3716249 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3702278..3716249 13971
flank IS/Tn - - 3711431..3711712 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T270618 WP_000994224.1 NZ_CP117338:3713287-3713562 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT270618 NZ_CP117338:c3713552-3713130 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References