239411

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3639847..3640260 Replicon chromosome
Accession NZ_CP094269
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain JL228

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag MPK88_RS18040 Protein ID WP_000994230.1
Coordinates 3640003..3640260 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3639847..3640178 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPK88_RS18000 3635108..3635605 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
MPK88_RS18005 3636368..3636938 - 571 Protein_3520 integrase core domain-containing protein -
MPK88_RS18010 3636859..3637068 - 210 WP_001676010.1 hypothetical protein -
MPK88_RS18015 3637121..3637435 + 315 WP_072100769.1 SymE family type I addiction module toxin -
MPK88_RS18020 3637502..3637780 - 279 WP_012543321.1 hypothetical protein -
MPK88_RS18025 3638097..3638564 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
MPK88_RS18030 3638561..3638878 - 318 WP_001751277.1 hypothetical protein -
MPK88_RS18035 3639436..3639669 - 234 WP_124084119.1 hypothetical protein -
- 3639847..3640178 - 332 - - Antitoxin
MPK88_RS18040 3640003..3640260 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
MPK88_RS18045 3640326..3640772 - 447 WP_000171102.1 hypothetical protein -
MPK88_RS18050 3640769..3644143 - 3375 Protein_3529 RHS repeat-associated core domain-containing protein -
MPK88_RS18055 3644143..3644649 - 507 Protein_3530 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3627212..3644065 16853
flank IS/Tn - - 3636368..3636646 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T239411 WP_000994230.1 NZ_CP094269:3640003-3640260 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T239411 NZ_LR890710:c5199039-5198656 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 332 bp

>AT239411 NZ_CP094269:c3640178-3639847 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCCG
GGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References