Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3170202..3170616 Replicon chromosome
Accession NZ_CP085816
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowpoke

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF68_RS15775 Protein ID WP_000994230.1
Coordinates 3170359..3170616 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3170202..3170534 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF68_RS15735 3165463..3165960 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF68_RS15740 3166723..3167293 - 571 Protein_3072 integrase core domain-containing protein -
LJF68_RS15745 3167214..3167423 - 210 WP_001676010.1 hypothetical protein -
LJF68_RS15750 3167476..3167790 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF68_RS15755 3167857..3168135 - 279 WP_012543321.1 hypothetical protein -
LJF68_RS15760 3168452..3168919 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF68_RS15765 3168916..3169233 - 318 WP_001751277.1 hypothetical protein -
LJF68_RS15770 3169791..3170024 - 234 WP_124084119.1 hypothetical protein -
- 3170202..3170534 - 333 - - Antitoxin
LJF68_RS15775 3170359..3170616 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF68_RS15780 3170682..3171128 - 447 WP_000171102.1 hypothetical protein -
LJF68_RS15785 3171125..3174499 - 3375 Protein_3081 RHS domain-containing protein -
LJF68_RS15790 3174499..3175005 - 507 Protein_3082 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3159894..3174421 14527
flank IS/Tn - - 3166723..3167001 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221892 WP_000994230.1 NZ_CP085816:3170359-3170616 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221892 NZ_CP117620:499211-499552 [Escherichia albertii]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGACTGAACCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTTGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGAGGCAGGCTACAGGTCAGCTGCGTCGCTG
CCATAACACCACGGCACGGTGA

Antitoxin


Download         Length: 333 bp

>AT221892 NZ_CP085816:c3170534-3170202 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References