233871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3734623..3735055 Replicon chromosome
Accession NZ_CP091571
Organism Salmonella enterica strain

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag INN74_RS18460 Protein ID WP_000994224.1
Coordinates 3734780..3735055 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3734623..3735045 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS18430 3730841..3731578 - 738 WP_001535430.1 pili assembly chaperone SafB -
INN74_RS18435 3731662..3732174 - 513 WP_077248260.1 pilus assembly protein -
INN74_RS18440 3732924..3733628 - 705 Protein_3613 integrase core domain-containing protein -
INN74_RS18445 3733681..3733929 + 249 WP_001738030.1 SymE family type I addiction module toxin -
INN74_RS18450 3734031..3734339 - 309 WP_010988969.1 hypothetical protein -
INN74_RS18455 3734422..3734538 - 117 WP_227457392.1 hypothetical protein -
- 3734623..3735045 - 423 - - Antitoxin
INN74_RS18460 3734780..3735055 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
INN74_RS18465 3735108..3735545 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
INN74_RS18470 3736108..3736554 - 447 WP_000935097.1 protein SciX -
INN74_RS18475 3736548..3737417 - 870 Protein_3620 polymorphic toxin type 47 domain-containing protein -
INN74_RS18480 3737481..3737744 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3723771..3737744 13973
flank IS/Tn - - 3732924..3733205 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T233871 WP_000994224.1 NZ_CP091571:3734780-3735055 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T233871 NZ_LN832404:c2092649-2092398 [Escherichia coli K-12]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 423 bp

>AT233871 NZ_CP091571:c3735045-3734623 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References