Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
Location | 994660..995092 | Replicon | chromosome |
Accession | NZ_CP091547 | ||
Organism | Salmonella enterica strain 1559 |
Toxin (Protein)
Gene name | IasE | Uniprot ID | E8XIW0 |
Locus tag | L4413_RS04705 | Protein ID | WP_000994224.1 |
Coordinates | 994660..994935 (-) | Length | 92 a.a. |
Antitoxin (RNA)
Gene name | IsrA | ||
Locus tag | - | ||
Coordinates | 994670..995092 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L4413_RS04685 | 991971..992234 | + | 264 | WP_000932531.1 | hypothetical protein | - |
L4413_RS04690 | 992298..993167 | + | 870 | Protein_909 | polymorphic toxin type 47 domain-containing protein | - |
L4413_RS04695 | 993161..993607 | + | 447 | WP_000935097.1 | protein SciX | - |
L4413_RS04700 | 994170..994607 | + | 438 | WP_000943619.1 | immunity 26/phosphotriesterase HocA family protein | - |
L4413_RS04705 | 994660..994935 | - | 276 | WP_000994224.1 | SymE family type I addiction module toxin | Toxin |
- | 994670..995092 | + | 423 | - | - | Antitoxin |
L4413_RS04710 | 995177..995293 | + | 117 | WP_227457392.1 | hypothetical protein | - |
L4413_RS04715 | 995376..995684 | + | 309 | WP_010988969.1 | hypothetical protein | - |
L4413_RS04720 | 995786..996034 | - | 249 | WP_001738030.1 | SymE family type I addiction module toxin | - |
L4413_RS04725 | 996087..996791 | + | 705 | Protein_916 | integrase core domain-containing protein | - |
L4413_RS04730 | 997541..998053 | + | 513 | WP_077248260.1 | pilus assembly protein | - |
L4413_RS04735 | 998137..998874 | + | 738 | WP_001535430.1 | pili assembly chaperone SafB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 992394..1006682 | 14288 | ||
flank | IS/Tn | - | - | 996510..996791 | 281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10032.36 Da Isoelectric Point: 6.4704
>T233651 WP_000994224.1 NZ_CP091547:c994935-994660 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
Download Length: 276 bp
>T233651 NZ_LK021128:59269-59565 [Vibrio anguillarum]
ATGTTCACTATAAAGCGCACGCAACTTTTTGATGATTGGTTGAAGACACTTAAAGATGCTCAGGCACGAGGTGCTATCAC
TGCTCGTGTTCAGCGCCTTACTCAGGGTTTGAGTGGGGATGTTAAGCCGGTTGGTTCGGGCATTAGTGAGCTTAGGATAC
ATGTCGGTAAAGGTTATCGAGTTTATTTTAAGCGTAGTGGAAAACAGATCGTTGTCTTACTTTGCGGTGGCAATAAGAAA
ACTCAGAATCAAGATATCGAACGCGCTAAAGAGTTGGTTCAATATTTTGATTTGTAG
ATGTTCACTATAAAGCGCACGCAACTTTTTGATGATTGGTTGAAGACACTTAAAGATGCTCAGGCACGAGGTGCTATCAC
TGCTCGTGTTCAGCGCCTTACTCAGGGTTTGAGTGGGGATGTTAAGCCGGTTGGTTCGGGCATTAGTGAGCTTAGGATAC
ATGTCGGTAAAGGTTATCGAGTTTATTTTAAGCGTAGTGGAAAACAGATCGTTGTCTTACTTTGCGGTGGCAATAAGAAA
ACTCAGAATCAAGATATCGAACGCGCTAAAGAGTTGGTTCAATATTTTGATTTGTAG
Antitoxin
Download Length: 423 bp
>AT233651 NZ_CP091547:994670-995092 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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