231159

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3826630..3827062 Replicon chromosome
Accession NZ_CP090545
Organism Salmonella enterica strain 2017028-SE

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L0F57_RS19070 Protein ID WP_000994224.1
Coordinates 3826787..3827062 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3826630..3827052 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F57_RS19040 3822848..3823585 - 738 WP_001535430.1 pili assembly chaperone SafB -
L0F57_RS19045 3823669..3824181 - 513 WP_077248260.1 pilus assembly protein -
L0F57_RS19050 3824931..3825635 - 705 Protein_3734 integrase core domain-containing protein -
L0F57_RS19055 3825688..3825936 + 249 WP_001738030.1 SymE family type I addiction module toxin -
L0F57_RS19060 3826038..3826346 - 309 WP_010988969.1 hypothetical protein -
L0F57_RS19065 3826429..3826545 - 117 WP_227457392.1 hypothetical protein -
- 3826630..3827052 - 423 - - Antitoxin
L0F57_RS19070 3826787..3827062 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
L0F57_RS19075 3827115..3827552 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L0F57_RS19080 3828115..3828561 - 447 WP_000935097.1 protein SciX -
L0F57_RS19085 3828555..3829424 - 870 Protein_3741 polymorphic toxin type 47 domain-containing protein -
L0F57_RS19090 3829488..3829751 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3815778..3829751 13973
flank IS/Tn - - 3824931..3825212 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T231159 WP_000994224.1 NZ_CP090545:3826787-3827062 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T231159 NZ_CP126095:1285597-1285947 [Paenibacillus sp. G2S3]
TTGATCGTTAAACGTGGCGATGTTTTTTTTGCTGATCTTTCGCCGGTTGTAGGTTCTGAGCAAGGCGGAGTAAGGCCAGT
ACTGGTTATCCAGAATGATATTGGCAATCGCTTTAGCCCGACGGTAATTGTGGCCGCAATCACGGCCCAAATCCAGAAGG
CTAAATTACCTACGCATGTGGAAATTGACGCAGCGGCTCATGGCTTTGACAGAGATTCTGTTATACTGCTGGAGCAGGTT
AGGACGATTGACAAACAACGCTTAACTGACAAGATCACCCACCTTGATGATGAAACAATGAAGAAGGTGGATGATTCGCT
GCAAATCAGCCTAGGGCTGATTGATTTTTAA

Antitoxin


Download         Length: 423 bp

>AT231159 NZ_CP090545:c3827052-3826630 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References