222040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2436629..2437043 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF58_RS12160 Protein ID WP_000994230.1
Coordinates 2436786..2437043 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2436629..2436961 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS12120 2431890..2432387 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF58_RS12125 2433150..2433720 - 571 Protein_2372 integrase core domain-containing protein -
LJF58_RS12130 2433641..2433850 - 210 WP_001676010.1 hypothetical protein -
LJF58_RS12135 2433903..2434217 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF58_RS12140 2434284..2434562 - 279 WP_012543321.1 hypothetical protein -
LJF58_RS12145 2434879..2435346 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF58_RS12150 2435343..2435660 - 318 WP_001751277.1 hypothetical protein -
LJF58_RS12155 2436218..2436451 - 234 WP_124084119.1 hypothetical protein -
- 2436629..2436961 - 333 - - Antitoxin
LJF58_RS12160 2436786..2437043 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF58_RS12165 2437109..2437555 - 447 WP_000171102.1 hypothetical protein -
LJF58_RS12170 2437552..2440926 - 3375 Protein_2381 RHS domain-containing protein -
LJF58_RS12175 2440926..2441432 - 507 Protein_2382 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2426321..2437043 10722
flank IS/Tn - - 2433150..2433428 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T222040 WP_000994230.1 NZ_CP085822:2436786-2437043 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T222040 NZ_CP117664:c1442-927 [Escherichia albertii]
ATGAAATTTTACACAATATCAAGCAGTTACATAAAATACCTGAAGGACTTTGATGACAAAGTTCCCAATAGCGAAGATCC
TACATACAACAATCCTAAGGCTTTCATTGGCATAGTACTAGAGATTGAAGGACATAAATATTTAGCACCTTTAACATCGC
CAAAAGCATGGCATGCTAATGTAAAAGAGTCATCACCCGCCTTCTTCAAACTTCATGAAAACGGTGTCCCTGATAATCAG
CTTGGATTGATTAATCTGAAATTTATGATTCCAATAATCGAAGCTGAAGTGTCTTTACTTGATCTGGATAGCATGCCTGA
TACGCCTTACAAAAGAATGCTATATAAACAGTTACAATTTATTCGTGTAAATGAAGATAAAATATCTGAAAAATCAAAAC
TATTAAGAAACCTTGCCTTGCAAGGCAGAATGCAAGGAACATGCGACTTTGCCGTGTTAGAAGAAAAATATCAACATTTC
GGTAAAAAACCTGAAGACATGGAAATAGACGATTAA

Antitoxin


Download         Length: 333 bp

>AT222040 NZ_CP085822:c2436961-2436629 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References