252085

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3777912..3778344 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NMU37_RS18745 Protein ID WP_000994224.1
Coordinates 3778069..3778344 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3777912..3778334 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS18715 3774130..3774867 - 738 WP_001535430.1 pili assembly chaperone SafB -
NMU37_RS18720 3774951..3775463 - 513 WP_077248260.1 pilus assembly protein -
NMU37_RS18725 3776213..3776917 - 705 Protein_3664 integrase core domain-containing protein -
NMU37_RS18730 3776970..3777218 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NMU37_RS18735 3777320..3777628 - 309 WP_010988969.1 hypothetical protein -
NMU37_RS18740 3777711..3777827 - 117 WP_227457392.1 hypothetical protein -
- 3777912..3778334 - 423 - - Antitoxin
NMU37_RS18745 3778069..3778344 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NMU37_RS18750 3778397..3778834 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NMU37_RS18755 3779397..3779843 - 447 WP_000935097.1 protein SciX -
NMU37_RS18760 3779837..3780706 - 870 Protein_3671 polymorphic toxin type 47 domain-containing protein -
NMU37_RS18765 3780770..3781033 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3767060..3781033 13973
flank IS/Tn - - 3776213..3776494 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T252085 WP_000994224.1 NZ_CP101386:3778069-3778344 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT252085 NZ_CP101386:c3778334-3777912 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References