271169

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3761158..3761590 Replicon chromosome
Accession NZ_CP117400
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM014

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQP96_RS18705 Protein ID WP_000994224.1
Coordinates 3761315..3761590 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3761158..3761580 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP96_RS18675 3757376..3758113 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQP96_RS18680 3758197..3758709 - 513 WP_077905298.1 pilus assembly protein -
PQP96_RS18685 3759459..3760163 - 705 Protein_3653 integrase core domain-containing protein -
PQP96_RS18690 3760216..3760464 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQP96_RS18695 3760566..3760874 - 309 WP_010988969.1 hypothetical protein -
PQP96_RS18700 3760957..3761073 - 117 WP_227457392.1 hypothetical protein -
- 3761158..3761580 - 423 - - Antitoxin
PQP96_RS18705 3761315..3761590 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQP96_RS18710 3761643..3762080 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQP96_RS18715 3762643..3763089 - 447 WP_000935097.1 protein SciX -
PQP96_RS18720 3763083..3763952 - 870 Protein_3660 polymorphic toxin type 47 domain-containing protein -
PQP96_RS18725 3764016..3764279 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3750306..3764279 13973
flank IS/Tn - - 3759459..3759740 281
- inside Prophage - gtrA / gtrB / gmhA/lpcA 3652517..3771045 118528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T271169 WP_000994224.1 NZ_CP117400:3761315-3761590 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT271169 NZ_CP117400:c3761580-3761158 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References