247960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3410980..3411412 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NCG87_RS16280 Protein ID WP_000994224.1
Coordinates 3410980..3411255 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3410990..3411412 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS16260 3408291..3408554 + 264 WP_000932531.1 hypothetical protein -
NCG87_RS16265 3408618..3409487 + 870 Protein_3160 polymorphic toxin type 47 domain-containing protein -
NCG87_RS16270 3409481..3409927 + 447 WP_000935097.1 protein SciX -
NCG87_RS16275 3410490..3410927 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NCG87_RS16280 3410980..3411255 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 3410990..3411412 + 423 - - Antitoxin
NCG87_RS16285 3411497..3411613 + 117 WP_227457392.1 hypothetical protein -
NCG87_RS16290 3411696..3412004 + 309 WP_010988969.1 hypothetical protein -
NCG87_RS16295 3412106..3412354 - 249 WP_001738030.1 SymE family type I addiction module toxin -
NCG87_RS16300 3412407..3413111 + 705 Protein_3167 integrase core domain-containing protein -
NCG87_RS16305 3413861..3414373 + 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
NCG87_RS16310 3414457..3415194 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3408714..3423002 14288
flank IS/Tn - - 3412830..3413111 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T247960 WP_000994224.1 NZ_CP098741:c3411255-3410980 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT247960 NZ_CP098741:3410990-3411412 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References