37464

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3657019..3657451 Replicon chromosome
Accession NZ_AP023309
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4578

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5680_RS17950 Protein ID WP_000994224.1
Coordinates 3657176..3657451 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3657019..3657441 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5680_RS17920 3653237..3653974 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5680_RS17925 3654058..3654570 - 513 WP_077248260.1 pilus assembly protein -
K5680_RS17930 3655320..3656024 - 705 Protein_3526 integrase core domain-containing protein -
K5680_RS17935 3656077..3656325 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5680_RS17940 3656427..3656735 - 309 WP_010988969.1 hypothetical protein -
K5680_RS17945 3656818..3656991 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3657019..3657441 - 423 - - Antitoxin
K5680_RS17950 3657176..3657451 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5680_RS17955 3657504..3657941 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K5680_RS17960 3658504..3658950 - 447 WP_000935097.1 protein SciX -
K5680_RS17965 3658944..3659813 - 870 Protein_3533 polymorphic toxin type 47 domain-containing protein -
K5680_RS17970 3659877..3660140 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3646167..3660140 13973
flank IS/Tn - - 3655320..3655601 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37464 WP_000994224.1 NZ_AP023309:3657176-3657451 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37464 NZ_AP023309:3657176-3657451 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37464 NZ_AP023309:c3657441-3657019 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References