207652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3765492..3765906 Replicon chromosome
Accession NZ_CP077711
Organism Salmonella enterica subsp. enterica strain CFSAN058606

Toxin (Protein)


Gene name IasE Uniprot ID A0A5Y7XEW6
Locus tag DAX63_RS18540 Protein ID WP_000994226.1
Coordinates 3765649..3765906 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3765492..3765824 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX63_RS18515 3761716..3762456 - 741 WP_023240606.1 pili assembly chaperone SafB -
DAX63_RS18520 3762531..3763028 - 498 WP_023240607.1 Saf-pilin pilus formation protein SafA -
DAX63_RS18525 3763796..3764497 - 702 Protein_3649 integrase core domain-containing protein -
DAX63_RS18530 3764550..3764864 + 315 WP_077907327.1 SymE family type I addiction module toxin -
DAX63_RS18535 3764931..3765209 - 279 WP_012664366.1 hypothetical protein -
- 3765492..3765824 - 333 - - Antitoxin
DAX63_RS18540 3765649..3765906 + 258 WP_000994226.1 SymE family type I addiction module toxin Toxin
DAX63_RS18545 3765997..3766374 - 378 WP_000739708.1 Imm8 family immunity protein -
DAX63_RS18550 3766694..3766855 - 162 WP_001658759.1 RHS repeat-associated core domain-containing protein -
DAX63_RS18555 3767028..3767366 - 339 WP_000357802.1 hypothetical protein -
DAX63_RS18560 3767633..3767944 - 312 WP_001220174.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3745310..3790590 45280
flank IS/Tn - - 3763796..3764074 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9547.82 Da        Isoelectric Point: 5.0770

>T207652 WP_000994226.1 NZ_CP077711:3765649-3765906 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGRSVTVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Download         Length: 258 bp

>T207652 NZ_CP103465:c3862750-3862436 [Escherichia coli O25b:H4-ST131]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 333 bp

>AT207652 NZ_CP077711:c3765824-3765492 [Salmonella enterica subsp. enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCAGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y7XEW6

Antitoxin

Download structure file

References