221936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 932658..933072 Replicon chromosome
Accession NZ_CP085818
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF66_RS04305 Protein ID WP_000994230.1
Coordinates 932658..932915 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 932740..933072 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF66_RS04290 928269..928775 + 507 Protein_822 phage late control D family protein -
LJF66_RS04295 928775..932149 + 3375 Protein_823 RHS domain-containing protein -
LJF66_RS04300 932146..932592 + 447 WP_000171102.1 hypothetical protein -
LJF66_RS04305 932658..932915 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 932740..933072 + 333 - - Antitoxin
LJF66_RS04310 933250..933483 + 234 WP_124084119.1 hypothetical protein -
LJF66_RS04315 934041..934358 + 318 WP_001751277.1 hypothetical protein -
LJF66_RS04320 934355..934822 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF66_RS04325 935139..935417 + 279 WP_012543321.1 hypothetical protein -
LJF66_RS04330 935484..935798 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF66_RS04335 935851..936060 + 210 WP_001676010.1 hypothetical protein -
LJF66_RS04340 935981..936551 + 571 Protein_832 integrase core domain-containing protein -
LJF66_RS04345 937314..937811 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 927354..946445 19091
flank IS/Tn - - 936273..936551 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221936 WP_000994230.1 NZ_CP085818:c932915-932658 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221936 NZ_CP117637:893143-893547 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCTGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 333 bp

>AT221936 NZ_CP085818:932740-933072 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References