233846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3706118..3706550 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag INN75_RS18340 Protein ID WP_000994224.1
Coordinates 3706275..3706550 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3706118..3706540 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS18310 3702336..3703073 - 738 WP_001535430.1 pili assembly chaperone SafB -
INN75_RS18315 3703157..3703669 - 513 WP_077248260.1 pilus assembly protein -
INN75_RS18320 3704419..3705123 - 705 Protein_3589 integrase core domain-containing protein -
INN75_RS18325 3705176..3705424 + 249 WP_001738030.1 SymE family type I addiction module toxin -
INN75_RS18330 3705526..3705834 - 309 WP_010988969.1 hypothetical protein -
INN75_RS18335 3705917..3706033 - 117 WP_227457392.1 hypothetical protein -
- 3706118..3706540 - 423 - - Antitoxin
INN75_RS18340 3706275..3706550 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
INN75_RS18345 3706603..3707040 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
INN75_RS18350 3707603..3708049 - 447 WP_000935097.1 protein SciX -
INN75_RS18355 3708043..3708912 - 870 Protein_3596 polymorphic toxin type 47 domain-containing protein -
INN75_RS18360 3708976..3709239 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3695266..3709239 13973
flank IS/Tn - - 3704419..3704700 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T233846 WP_000994224.1 NZ_CP091569:3706275-3706550 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T233846 NZ_LN831039:c727206-726775 [Mycolicibacterium smegmatis]
ATGTTCCTGCTAGACGTGAACGTCGTACTTGCGGCATACCGCGCAGACCACCCAGATCACGCCACCGTGCGTCCGTGGTT
CGATCGCCTGCTCGATGGCGACGGACCGTTCACCGTCCCGGTACAGGTGTGGGCGTCGTTCCTGCGATTGGTAACCAATC
GGCGTATCTTCCCAGTCCCCACACCCCGTGACGATGCGTTCGCGTTCATCGAAGCCGTCAACGGCCAACCGCACCACGTG
CCGGTAAGCGCGGGCCCGCGGCACCTTGCGCTGCTGCACCAACTTTGCGACGAAGGCGATGCCTCCGGCGACCTGATCCC
CGATGCAGTGCTCGCGGCCATCGCCCACGAACATCATTGCGACGTGGCGACTCTCGATCGGGACTTCGCCCGATTCACCA
CGGTCCGTCATCTGAGGCCGAGTCTGGACTGA

Antitoxin


Download         Length: 423 bp

>AT233846 NZ_CP091569:c3706540-3706118 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References