221102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3730083..3730515 Replicon chromosome
Accession NZ_CP085699
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S29

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag LJN59_RS18485 Protein ID WP_000994224.1
Coordinates 3730240..3730515 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3730083..3730505 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN59_RS18455 3726301..3727038 - 738 WP_001535430.1 pili assembly chaperone SafB -
LJN59_RS18460 3727122..3727634 - 513 WP_077248260.1 pilus assembly protein -
LJN59_RS18465 3728384..3729088 - 705 Protein_3614 integrase core domain-containing protein -
LJN59_RS18470 3729141..3729389 + 249 WP_001738030.1 SymE family type I addiction module toxin -
LJN59_RS18475 3729491..3729799 - 309 WP_010988969.1 hypothetical protein -
LJN59_RS18480 3729882..3729998 - 117 WP_227457392.1 hypothetical protein -
- 3730083..3730505 - 423 - - Antitoxin
LJN59_RS18485 3730240..3730515 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
LJN59_RS18490 3730568..3731005 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
LJN59_RS18495 3731568..3732014 - 447 WP_000935097.1 protein SciX -
LJN59_RS18500 3732008..3732877 - 870 Protein_3621 polymorphic toxin type 47 domain-containing protein -
LJN59_RS18505 3732941..3733204 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3728384..3728665 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T221102 WP_000994224.1 NZ_CP085699:3730240-3730515 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T221102 NZ_CP117343:3545614-3545832 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 423 bp

>AT221102 NZ_CP085699:c3730505-3730083 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References