203067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3595952..3596366 Replicon chromosome
Accession NZ_CP075122
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag BCA48_RS17575 Protein ID WP_000994230.1
Coordinates 3596109..3596366 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3595952..3596284 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCA48_RS17535 3591213..3591710 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
BCA48_RS17540 3592473..3593043 - 571 Protein_3448 integrase core domain-containing protein -
BCA48_RS17545 3592964..3593173 - 210 WP_001676010.1 hypothetical protein -
BCA48_RS17550 3593226..3593540 + 315 WP_072100769.1 SymE family type I addiction module toxin -
BCA48_RS17555 3593607..3593885 - 279 WP_012543321.1 hypothetical protein -
BCA48_RS17560 3594202..3594669 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
BCA48_RS17565 3594666..3594983 - 318 WP_001751277.1 hypothetical protein -
BCA48_RS17570 3595541..3595774 - 234 WP_124084119.1 hypothetical protein -
- 3595952..3596284 - 333 - - Antitoxin
BCA48_RS17575 3596109..3596366 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
BCA48_RS17580 3596432..3596878 - 447 WP_000171102.1 hypothetical protein -
BCA48_RS17585 3596875..3600249 - 3375 Protein_3457 RHS domain-containing protein -
BCA48_RS17590 3600249..3600755 - 507 Protein_3458 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3583317..3600171 16854
flank IS/Tn - - 3592473..3592751 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T203067 WP_000994230.1 NZ_CP075122:3596109-3596366 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T203067 NZ_CP099873:c8123-7857 [Escherichia albertii]
ATGAAGATACGAAAAGGTGACAGGCAATATTATTTGAATAAAGAAGGTAATATGTTTCATCTTGTGAAACGGGTGAAGAC
CTTTTCTAAATCTGCGACTTTAGGGAAAACAAAAGCGACAGTGATAACTGTTGCCGATCTAATTTTTCATGAAGATGCAT
TCGACACTATCGACTTTACCAGAGGCGGGTTAAGAGAGAACGACAAAGAAGTTGTTTCTATGATGATTCAGGAAATGAAC
AATGAACGAGAAAAAAATGTTAACTGA

Antitoxin


Download         Length: 333 bp

>AT203067 NZ_CP075122:c3596284-3595952 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References