251978

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3758485..3758917 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NMU32_RS18630 Protein ID WP_000994224.1
Coordinates 3758642..3758917 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3758485..3758907 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS18600 3754703..3755440 - 738 WP_001535430.1 pili assembly chaperone SafB -
NMU32_RS18605 3755524..3756036 - 513 WP_077248260.1 pilus assembly protein -
NMU32_RS18610 3756786..3757490 - 705 Protein_3641 integrase core domain-containing protein -
NMU32_RS18615 3757543..3757791 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NMU32_RS18620 3757893..3758201 - 309 WP_010988969.1 hypothetical protein -
NMU32_RS18625 3758284..3758400 - 117 WP_227457392.1 hypothetical protein -
- 3758485..3758907 - 423 - - Antitoxin
NMU32_RS18630 3758642..3758917 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NMU32_RS18635 3758970..3759407 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NMU32_RS18640 3759970..3760416 - 447 WP_000935097.1 protein SciX -
NMU32_RS18645 3760410..3761279 - 870 Protein_3648 polymorphic toxin type 47 domain-containing protein -
NMU32_RS18650 3761343..3761606 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3756786..3757067 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T251978 WP_000994224.1 NZ_CP101373:3758642-3758917 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT251978 NZ_CP101373:c3758907-3758485 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References