37185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3762565..3762997 Replicon chromosome
Accession NZ_AP023288
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3835

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5610_RS18715 Protein ID WP_000994224.1
Coordinates 3762722..3762997 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3762565..3762987 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5610_RS18685 3758783..3759520 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5610_RS18690 3759604..3760116 - 513 WP_077248260.1 pilus assembly protein -
K5610_RS18695 3760866..3761570 - 705 Protein_3674 integrase core domain-containing protein -
K5610_RS18700 3761623..3761871 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5610_RS18705 3761973..3762281 - 309 WP_010988969.1 hypothetical protein -
K5610_RS18710 3762364..3762537 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3762565..3762987 - 423 - - Antitoxin
K5610_RS18715 3762722..3762997 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5610_RS18720 3763050..3763487 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K5610_RS18725 3764050..3764496 - 447 WP_000935097.1 protein SciX -
K5610_RS18730 3764490..3765359 - 870 Protein_3681 polymorphic toxin type 47 domain-containing protein -
K5610_RS18735 3765423..3765686 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3751713..3765686 13973
flank IS/Tn - - 3760866..3761147 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37185 WP_000994224.1 NZ_AP023288:3762722-3762997 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37185 NZ_AP023288:3762722-3762997 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37185 NZ_AP023288:c3762987-3762565 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References