282701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 544517..544931 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag NED09_RS02780 Protein ID WP_000994230.1
Coordinates 544674..544931 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 544517..544849 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS02740 539778..540275 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
NED09_RS02745 541038..541608 - 571 Protein_531 integrase core domain-containing protein -
NED09_RS02750 541529..541738 - 210 WP_001676010.1 hypothetical protein -
NED09_RS02755 541791..542105 + 315 WP_072100769.1 SymE family type I addiction module toxin -
NED09_RS02760 542172..542450 - 279 WP_012543321.1 hypothetical protein -
NED09_RS02765 542767..543234 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
NED09_RS02770 543231..543548 - 318 WP_001751277.1 hypothetical protein -
NED09_RS02775 544106..544339 - 234 WP_124084119.1 hypothetical protein -
- 544517..544849 - 333 - - Antitoxin
NED09_RS02780 544674..544931 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
NED09_RS02785 544997..545443 - 447 WP_000171102.1 hypothetical protein -
NED09_RS02790 545440..548814 - 3375 Protein_540 RHS repeat-associated core domain-containing protein -
NED09_RS02795 548814..549320 - 507 Protein_541 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 531882..548736 16854
flank IS/Tn - - 541038..541316 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-56)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T282701 WP_000994230.1 NZ_CP126166:544674-544931 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp


Antitoxin


Download         Length: 333 bp

>AT282701 NZ_CP126166:c544849-544517 [Salmonella enterica subsp. enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656IER2


Antitoxin

Download structure file

References