Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 544517..544931 | Replicon | chromosome |
| Accession | NZ_CP126166 | ||
| Organism | Salmonella enterica subsp. enterica strain CRSE-01 | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | M7RBD3 |
| Locus tag | NED09_RS02780 | Protein ID | WP_000994230.1 |
| Coordinates | 544674..544931 (+) | Length | 86 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 544517..544849 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NED09_RS02740 | 539778..540275 | - | 498 | WP_016695185.1 | Saf-pilin pilus formation protein | - |
| NED09_RS02745 | 541038..541608 | - | 571 | Protein_531 | integrase core domain-containing protein | - |
| NED09_RS02750 | 541529..541738 | - | 210 | WP_001676010.1 | hypothetical protein | - |
| NED09_RS02755 | 541791..542105 | + | 315 | WP_072100769.1 | SymE family type I addiction module toxin | - |
| NED09_RS02760 | 542172..542450 | - | 279 | WP_012543321.1 | hypothetical protein | - |
| NED09_RS02765 | 542767..543234 | - | 468 | WP_000828182.1 | sugar tyrosine-protein kinase | - |
| NED09_RS02770 | 543231..543548 | - | 318 | WP_001751277.1 | hypothetical protein | - |
| NED09_RS02775 | 544106..544339 | - | 234 | WP_124084119.1 | hypothetical protein | - |
| - | 544517..544849 | - | 333 | - | - | Antitoxin |
| NED09_RS02780 | 544674..544931 | + | 258 | WP_000994230.1 | SymE family type I addiction module toxin | Toxin |
| NED09_RS02785 | 544997..545443 | - | 447 | WP_000171102.1 | hypothetical protein | - |
| NED09_RS02790 | 545440..548814 | - | 3375 | Protein_540 | RHS repeat-associated core domain-containing protein | - |
| NED09_RS02795 | 548814..549320 | - | 507 | Protein_541 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 531882..548736 | 16854 | |
| flank | IS/Tn | - | - | 541038..541316 | 278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9490.94 Da Isoelectric Point: 9.5519
>T282701 WP_000994230.1 NZ_CP126166:544674-544931 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
Download Length: 258 bp
Antitoxin
Download Length: 333 bp
>AT282701 NZ_CP126166:c544849-544517 [Salmonella enterica subsp. enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
