185711

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 339229..339661 Replicon chromosome
Accession NZ_CP067091
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag JJB80_RS01500 Protein ID WP_000994224.1
Coordinates 339229..339504 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 339239..339661 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB80_RS01480 336540..336803 + 264 WP_000932531.1 hypothetical protein -
JJB80_RS01485 336867..337736 + 870 Protein_288 polymorphic toxin type 47 domain-containing protein -
JJB80_RS01490 337730..338176 + 447 WP_000935097.1 protein SciX -
JJB80_RS01495 338739..339176 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
JJB80_RS01500 339229..339504 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 339239..339661 + 423 - - Antitoxin
JJB80_RS23730 339689..339862 + 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
JJB80_RS01510 339945..340253 + 309 WP_010988969.1 hypothetical protein -
JJB80_RS01515 340355..340603 - 249 WP_001738030.1 SymE family type I addiction module toxin -
JJB80_RS01520 340656..341360 + 705 Protein_295 integrase core domain-containing protein -
JJB80_RS01525 342110..342622 + 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
JJB80_RS01530 342706..343443 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 316094..351251 35157
flank IS/Tn - - 341079..341360 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T185711 WP_000994224.1 NZ_CP067091:c339504-339229 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T185711 NZ_CP089001:1457638-1458054 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 423 bp

>AT185711 NZ_CP067091:339239-339661 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References