265909

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3779885..3780317 Replicon chromosome
Accession NZ_CP113535
Organism Salmonella enterica strain ZLQ

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag OXV11_RS18805 Protein ID WP_000994224.1
Coordinates 3780042..3780317 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3779885..3780307 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV11_RS18775 3776103..3776840 - 738 WP_001535430.1 pili assembly chaperone SafB -
OXV11_RS18780 3776924..3777436 - 513 WP_077248260.1 pilus assembly protein -
OXV11_RS18785 3778186..3778890 - 705 Protein_3678 integrase core domain-containing protein -
OXV11_RS18790 3778943..3779191 + 249 WP_001738030.1 SymE family type I addiction module toxin -
OXV11_RS18795 3779293..3779601 - 309 WP_010988969.1 hypothetical protein -
OXV11_RS18800 3779684..3779800 - 117 WP_227457392.1 hypothetical protein -
- 3779885..3780307 - 423 - - Antitoxin
OXV11_RS18805 3780042..3780317 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
OXV11_RS18810 3780370..3780807 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
OXV11_RS18815 3781370..3781816 - 447 WP_000935097.1 protein SciX -
OXV11_RS18820 3781810..3782679 - 870 Protein_3685 polymorphic toxin type 47 domain-containing protein -
OXV11_RS18825 3782743..3783006 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3769033..3783006 13973
flank IS/Tn - - 3778186..3778467 281
- inside Prophage - sopE2 / gmhA/lpcA 3671353..3789772 118419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T265909 WP_000994224.1 NZ_CP113535:3780042-3780317 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT265909 NZ_CP113535:c3780307-3779885 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References