233764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3714827..3715259 Replicon chromosome
Accession NZ_CP091560
Organism Salmonella enterica strain 179

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag INN78_RS18435 Protein ID WP_000994224.1
Coordinates 3714984..3715259 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3714827..3715249 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN78_RS18405 3711045..3711782 - 738 WP_001535430.1 pili assembly chaperone SafB -
INN78_RS18410 3711866..3712378 - 513 WP_077248260.1 pilus assembly protein -
INN78_RS18415 3713128..3713832 - 705 Protein_3608 integrase core domain-containing protein -
INN78_RS18420 3713885..3714133 + 249 WP_001738030.1 SymE family type I addiction module toxin -
INN78_RS18425 3714235..3714543 - 309 WP_010988969.1 hypothetical protein -
INN78_RS18430 3714626..3714742 - 117 WP_227457392.1 hypothetical protein -
- 3714827..3715249 - 423 - - Antitoxin
INN78_RS18435 3714984..3715259 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
INN78_RS18440 3715312..3715749 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
INN78_RS18445 3716312..3716758 - 447 WP_000935097.1 protein SciX -
INN78_RS18450 3716752..3717621 - 870 Protein_3615 polymorphic toxin type 47 domain-containing protein -
INN78_RS18455 3717685..3717948 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3703975..3717948 13973
flank IS/Tn - - 3713128..3713409 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T233764 WP_000994224.1 NZ_CP091560:3714984-3715259 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T233764 NZ_LN681227:180177-180575 [Xenorhabdus nematophila AN6/1]
ATGATATGGGTCAGCGCACAGGAAGTTATCGCTTTTCATGACCGAATATTACAACGGCTTCCCGGCGTTGCCGGAATGCC
CGATTCTGGTAGAGCTGAAGCGCTCATCTATCGGGTACAAAACCGTACACACCATGAAGGCATAACAGATATTTTTGAAC
TTGCAGCTACCTATTGGGCTGCTATCGCTCGTGGTCATATTTTCAATGATGGTAATAAGCGCACAGCGTTTTTCGTTACC
ATGACTTTTCTCTATCGTAACGGTATCAAGATCCGTGATAACGACAATACATTGGAAAACTTAACAGTAGATGCCGCTAC
GGGCGAGAAAACCGTTGACCAGTTGGCGCAGCACCTGCGCGAATTGGTGGACTATACTAACCCGAGCTGTAATCCATGA

Antitoxin


Download         Length: 423 bp

>AT233764 NZ_CP091560:c3715249-3714827 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References