170688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1852296..1852710 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag H9Q83_RS09550 Protein ID WP_000994230.1
Coordinates 1852453..1852710 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1852296..1852628 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS09510 1847557..1848054 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
H9Q83_RS09515 1848817..1849387 - 571 Protein_1861 integrase core domain-containing protein -
H9Q83_RS09520 1849308..1849517 - 210 WP_001676010.1 hypothetical protein -
H9Q83_RS09525 1849570..1849884 + 315 WP_072100769.1 SymE family type I addiction module toxin -
H9Q83_RS09530 1849951..1850229 - 279 WP_012543321.1 hypothetical protein -
H9Q83_RS09535 1850546..1851013 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
H9Q83_RS09540 1851010..1851327 - 318 WP_001751277.1 hypothetical protein -
H9Q83_RS09545 1851885..1852118 - 234 WP_124084119.1 hypothetical protein -
- 1852296..1852628 - 333 - - Antitoxin
H9Q83_RS09550 1852453..1852710 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
H9Q83_RS09555 1852776..1853222 - 447 WP_000171102.1 hypothetical protein -
H9Q83_RS09560 1853219..1856593 - 3375 Protein_1870 RHS domain-containing protein -
H9Q83_RS09565 1856593..1857099 - 507 Protein_1871 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1839661..1856515 16854
flank IS/Tn - - 1848817..1849095 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T170688 WP_000994230.1 NZ_CP060676:1852453-1852710 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T170688 NZ_CP077678:c323507-323079 [Pseudomonas chlororaphis]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCTATGACCATGGCCGAGATTCTCCACGGTATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGGTGGCCATGTTCGAGGAAGACTTCATCGACCGGATCGTGCCCTTCGGAACC
CAAGCGGCTCTTTACTACGCGCATCTGGTTTCGCATCGCGAAAGATCAGGCCAGCCGATCAATCTGGTGGATGCGCAAAT
TGCAGCGATATGCCGGGTCCACGACGCCGCGATCGCCACTCGTAACACCAAGGATTTCACCGACACCGGGCTGATCGTTA
TCAACCCCTGGCTGCCGCTCGAGGTCTGA

Antitoxin


Download         Length: 333 bp

>AT170688 NZ_CP060676:c1852628-1852296 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References