202942

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736272..3736686 Replicon chromosome
Accession NZ_CP075113
Organism Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag CCO47_RS18460 Protein ID WP_000994230.1
Coordinates 3736429..3736686 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736272..3736604 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO47_RS18420 3731533..3731985 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
CCO47_RS18425 3732794..3733364 - 571 Protein_3631 integrase core domain-containing protein -
CCO47_RS18430 3733285..3733494 - 210 WP_001676010.1 hypothetical protein -
CCO47_RS18435 3733547..3733861 + 315 WP_072100769.1 SymE family type I addiction module toxin -
CCO47_RS18440 3733928..3734206 - 279 WP_012543321.1 hypothetical protein -
CCO47_RS18445 3734522..3734989 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
CCO47_RS18450 3734986..3735303 - 318 WP_176210647.1 hypothetical protein -
CCO47_RS18455 3735861..3736094 - 234 WP_124084119.1 hypothetical protein -
- 3736272..3736604 - 333 - - Antitoxin
CCO47_RS18460 3736429..3736686 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
CCO47_RS18465 3736752..3737198 - 447 WP_000171102.1 hypothetical protein -
CCO47_RS18470 3737195..3740017 - 2823 Protein_3640 RHS domain-containing protein -
CCO47_RS18475 3740065..3740274 + 210 WP_001675680.1 SymE family type I addiction module toxin -
CCO47_RS18480 3740392..3740730 - 339 WP_000201550.1 hypothetical protein -
CCO47_RS18485 3740752..3741072 - 321 WP_016695071.1 HNH endonuclease -
CCO47_RS24285 3741130..3741413 - 284 Protein_3644 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3723638..3741966 18328
flank IS/Tn - - 3732794..3733072 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T202942 WP_000994230.1 NZ_CP075113:3736429-3736686 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T202942 NZ_CP099754:c2646545-2646369 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 333 bp

>AT202942 NZ_CP075113:c3736604-3736272 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References