Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 3636410..3636824 | Replicon | chromosome |
| Accession | NZ_CP120318 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_2_2022 | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | M7RBD3 |
| Locus tag | P1703_RS17985 | Protein ID | WP_000994230.1 |
| Coordinates | 3636567..3636824 (+) | Length | 86 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 3636410..3636742 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P1703_RS17945 | 3631671..3632168 | - | 498 | WP_016695185.1 | Saf-pilin pilus formation protein | - |
| P1703_RS17950 | 3632931..3633501 | - | 571 | Protein_3509 | integrase core domain-containing protein | - |
| P1703_RS17955 | 3633422..3633631 | - | 210 | WP_001676010.1 | hypothetical protein | - |
| P1703_RS17960 | 3633684..3633998 | + | 315 | WP_072100769.1 | SymE family type I addiction module toxin | - |
| P1703_RS17965 | 3634065..3634343 | - | 279 | WP_012543321.1 | hypothetical protein | - |
| P1703_RS17970 | 3634660..3635127 | - | 468 | WP_000828182.1 | sugar tyrosine-protein kinase | - |
| P1703_RS17975 | 3635124..3635441 | - | 318 | WP_001751277.1 | hypothetical protein | - |
| P1703_RS17980 | 3635999..3636232 | - | 234 | WP_124084119.1 | hypothetical protein | - |
| - | 3636410..3636742 | - | 333 | - | - | Antitoxin |
| P1703_RS17985 | 3636567..3636824 | + | 258 | WP_000994230.1 | SymE family type I addiction module toxin | Toxin |
| P1703_RS17990 | 3636890..3637336 | - | 447 | WP_000171102.1 | hypothetical protein | - |
| P1703_RS17995 | 3637333..3640707 | - | 3375 | Protein_3518 | RHS repeat-associated core domain-containing protein | - |
| P1703_RS18000 | 3640707..3641213 | - | 507 | Protein_3519 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3625316..3640629 | 15313 | |
| flank | IS/Tn | - | - | 3632931..3633209 | 278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9490.94 Da Isoelectric Point: 9.5519
>T274633 WP_000994230.1 NZ_CP120318:3636567-3636824 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
Download Length: 258 bp
Antitoxin
Download Length: 333 bp
>AT274633 NZ_CP120318:c3636742-3636410 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
