146667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1232161..1232593 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN27_RS05755 Protein ID WP_000994224.1
Coordinates 1232161..1232436 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1232171..1232593 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN27_RS05735 1229472..1229735 + 264 WP_000932531.1 hypothetical protein -
DXN27_RS05740 1229799..1230668 + 870 Protein_1104 polymorphic toxin type 47 domain-containing protein -
DXN27_RS05745 1230662..1231108 + 447 WP_000935097.1 protein SciX -
DXN27_RS05750 1231671..1232108 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN27_RS05755 1232161..1232436 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 1232171..1232593 + 423 - - Antitoxin
DXN27_RS05760 1232678..1232794 + 117 WP_227457392.1 hypothetical protein -
DXN27_RS05765 1232877..1233185 + 309 WP_010988969.1 hypothetical protein -
DXN27_RS05770 1233287..1233535 - 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN27_RS05775 1233588..1234292 + 705 Protein_1111 integrase core domain-containing protein -
DXN27_RS05780 1235042..1235554 + 513 WP_077248260.1 pilus assembly protein -
DXN27_RS05785 1235638..1236375 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1234011..1234292 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146667 WP_000994224.1 NZ_CP047553:c1232436-1232161 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146667 NZ_CP062771:c2590347-2590069 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 423 bp

>AT146667 NZ_CP047553:1232171-1232593 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References