37281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3686381..3686813 Replicon chromosome
Accession NZ_AP023292
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4233

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5617_RS18140 Protein ID WP_000994224.1
Coordinates 3686538..3686813 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3686381..3686803 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5617_RS18110 3682599..3683336 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5617_RS18115 3683420..3683932 - 513 WP_077248260.1 pilus assembly protein -
K5617_RS18120 3684682..3685386 - 705 Protein_3563 integrase core domain-containing protein -
K5617_RS18125 3685439..3685687 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5617_RS18130 3685789..3686097 - 309 WP_010988969.1 hypothetical protein -
K5617_RS18135 3686180..3686353 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3686381..3686803 - 423 - - Antitoxin
K5617_RS18140 3686538..3686813 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5617_RS18145 3686866..3687303 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K5617_RS18150 3687866..3688312 - 447 WP_000935097.1 protein SciX -
K5617_RS18155 3688306..3689175 - 870 Protein_3570 polymorphic toxin type 47 domain-containing protein -
K5617_RS18160 3689239..3689502 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3675529..3689502 13973
flank IS/Tn - - 3684682..3684963 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37281 WP_000994224.1 NZ_AP023292:3686538-3686813 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37281 NZ_AP023292:3686538-3686813 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37281 NZ_AP023292:c3686803-3686381 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References