221957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 742739..743171 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag LJF65_RS03585 Protein ID WP_000994224.1
Coordinates 742896..743171 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 742739..743161 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS03555 738957..739694 - 738 WP_001535430.1 pili assembly chaperone SafB -
LJF65_RS03560 739778..740290 - 513 WP_105907557.1 pilus assembly protein -
LJF65_RS03565 741040..741744 - 705 Protein_694 integrase core domain-containing protein -
LJF65_RS03570 741797..742045 + 249 WP_001738030.1 SymE family type I addiction module toxin -
LJF65_RS03575 742147..742455 - 309 WP_010988969.1 hypothetical protein -
LJF65_RS03580 742538..742654 - 117 WP_227457392.1 hypothetical protein -
- 742739..743161 - 423 - - Antitoxin
LJF65_RS03585 742896..743171 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
LJF65_RS03590 743224..743661 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
LJF65_RS03595 744224..744670 - 447 WP_000935097.1 protein SciX -
LJF65_RS03600 744664..745533 - 870 Protein_701 polymorphic toxin type 47 domain-containing protein -
LJF65_RS03605 745597..745860 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 731887..745860 13973
flank IS/Tn - - 741040..741321 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T221957 WP_000994224.1 NZ_CP085819:742896-743171 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T221957 NZ_CP117643:2466237-2466515 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTAATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 423 bp

>AT221957 NZ_CP085819:c743161-742739 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References