170584

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3947168..3947582 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag H9Q87_RS19400 Protein ID WP_000994230.1
Coordinates 3947325..3947582 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3947168..3947500 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS19360 3942429..3942926 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
H9Q87_RS19365 3943689..3944259 - 571 Protein_3770 integrase core domain-containing protein -
H9Q87_RS19370 3944180..3944389 - 210 WP_001676010.1 hypothetical protein -
H9Q87_RS19375 3944442..3944756 + 315 WP_072100769.1 SymE family type I addiction module toxin -
H9Q87_RS19380 3944823..3945101 - 279 WP_012543321.1 hypothetical protein -
H9Q87_RS19385 3945418..3945885 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
H9Q87_RS19390 3945882..3946199 - 318 WP_001751277.1 hypothetical protein -
H9Q87_RS19395 3946757..3946990 - 234 WP_124084119.1 hypothetical protein -
- 3947168..3947500 - 333 - - Antitoxin
H9Q87_RS19400 3947325..3947582 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
H9Q87_RS19405 3947648..3948094 - 447 WP_000171102.1 hypothetical protein -
H9Q87_RS19410 3948091..3951465 - 3375 Protein_3779 RHS domain-containing protein -
H9Q87_RS19415 3951465..3951971 - 507 Protein_3780 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3934533..3951387 16854
flank IS/Tn - - 3943689..3943967 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T170584 WP_000994230.1 NZ_CP060668:3947325-3947582 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T170584 NZ_CP077649:1289535-1289753 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 333 bp

>AT170584 NZ_CP060668:c3947500-3947168 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References