231109

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3789883..3790315 Replicon chromosome
Accession NZ_CP090539
Organism Salmonella enterica strain 2016062-SE

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L0F59_RS18800 Protein ID WP_000994224.1
Coordinates 3790040..3790315 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3789883..3790305 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F59_RS18770 3786101..3786838 - 738 WP_001535430.1 pili assembly chaperone SafB -
L0F59_RS18775 3786922..3787434 - 513 WP_077248260.1 pilus assembly protein -
L0F59_RS18780 3788184..3788888 - 705 Protein_3681 integrase core domain-containing protein -
L0F59_RS18785 3788941..3789189 + 249 WP_001738030.1 SymE family type I addiction module toxin -
L0F59_RS18790 3789291..3789599 - 309 WP_010988969.1 hypothetical protein -
L0F59_RS18795 3789682..3789798 - 117 WP_227457392.1 hypothetical protein -
- 3789883..3790305 - 423 - - Antitoxin
L0F59_RS18800 3790040..3790315 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
L0F59_RS18805 3790368..3790805 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L0F59_RS18810 3791368..3791814 - 447 WP_000935097.1 protein SciX -
L0F59_RS18815 3791808..3792677 - 870 Protein_3688 polymorphic toxin type 47 domain-containing protein -
L0F59_RS18820 3792741..3793004 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3781355..3793004 11649
flank IS/Tn - - 3788184..3788465 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T231109 WP_000994224.1 NZ_CP090539:3790040-3790315 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T231109 NZ_CP125992:2412081-2412818 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 423 bp

>AT231109 NZ_CP090539:c3790305-3789883 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References