252019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3726439..3726871 Replicon chromosome
Accession NZ_CP101376
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NMU34_RS18465 Protein ID WP_000994224.1
Coordinates 3726596..3726871 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3726439..3726861 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS18435 3722657..3723394 - 738 WP_001535430.1 pili assembly chaperone SafB -
NMU34_RS18440 3723478..3723990 - 513 WP_077248260.1 pilus assembly protein -
NMU34_RS18445 3724740..3725444 - 705 Protein_3608 integrase core domain-containing protein -
NMU34_RS18450 3725497..3725745 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NMU34_RS18455 3725847..3726155 - 309 WP_010988969.1 hypothetical protein -
NMU34_RS18460 3726238..3726354 - 117 WP_227457392.1 hypothetical protein -
- 3726439..3726861 - 423 - - Antitoxin
NMU34_RS18465 3726596..3726871 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NMU34_RS18470 3726924..3727361 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NMU34_RS18475 3727924..3728370 - 447 WP_000935097.1 protein SciX -
NMU34_RS18480 3728364..3729233 - 870 Protein_3615 polymorphic toxin type 47 domain-containing protein -
NMU34_RS18485 3729297..3729560 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3715587..3729560 13973
flank IS/Tn - - 3724740..3725021 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T252019 WP_000994224.1 NZ_CP101376:3726596-3726871 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT252019 NZ_CP101376:c3726861-3726439 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References