181082

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3942400..3942832 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag IUJ38_RS18995 Protein ID WP_000994224.1
Coordinates 3942400..3942675 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3942410..3942832 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS18975 3939711..3939974 + 264 WP_000932531.1 hypothetical protein -
IUJ38_RS18980 3940038..3940907 + 870 Protein_3701 polymorphic toxin type 47 domain-containing protein -
IUJ38_RS18985 3940901..3941347 + 447 WP_000935097.1 protein SciX -
IUJ38_RS18990 3941910..3942347 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
IUJ38_RS18995 3942400..3942675 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 3942410..3942832 + 423 - - Antitoxin
IUJ38_RS19000 3942917..3943033 + 117 WP_227457392.1 hypothetical protein -
IUJ38_RS19005 3943116..3943424 + 309 WP_010988969.1 hypothetical protein -
IUJ38_RS19010 3943526..3943774 - 249 WP_001738030.1 SymE family type I addiction module toxin -
IUJ38_RS19015 3943827..3944531 + 705 Protein_3708 integrase core domain-containing protein -
IUJ38_RS19020 3945281..3945793 + 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
IUJ38_RS19025 3945877..3946614 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3940134..3954422 14288
flank IS/Tn - - 3944250..3944531 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T181082 WP_000994224.1 NZ_CP064385:c3942675-3942400 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T181082 NZ_CP085802:4448241-4448726 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 423 bp

>AT181082 NZ_CP064385:3942410-3942832 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References