203013

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3595932..3596346 Replicon chromosome
Accession NZ_CP075118
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag BCB09_RS17575 Protein ID WP_000994230.1
Coordinates 3596089..3596346 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3595932..3596264 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB09_RS17535 3591193..3591690 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
BCB09_RS17540 3592453..3593023 - 571 Protein_3447 integrase core domain-containing protein -
BCB09_RS17545 3592944..3593153 - 210 WP_001676010.1 hypothetical protein -
BCB09_RS17550 3593206..3593520 + 315 WP_072100769.1 SymE family type I addiction module toxin -
BCB09_RS17555 3593587..3593865 - 279 WP_012543321.1 hypothetical protein -
BCB09_RS17560 3594182..3594649 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
BCB09_RS17565 3594646..3594963 - 318 WP_001751277.1 hypothetical protein -
BCB09_RS17570 3595521..3595754 - 234 WP_124084119.1 hypothetical protein -
- 3595932..3596264 - 333 - - Antitoxin
BCB09_RS17575 3596089..3596346 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
BCB09_RS17580 3596412..3596858 - 447 WP_000171102.1 hypothetical protein -
BCB09_RS17585 3596855..3600229 - 3375 Protein_3456 RHS domain-containing protein -
BCB09_RS17590 3600229..3600735 - 507 Protein_3457 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3583297..3600151 16854
flank IS/Tn - - 3592453..3592731 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T203013 WP_000994230.1 NZ_CP075118:3596089-3596346 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T203013 NZ_CP099815:1969401-1969859 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin


Download         Length: 333 bp

>AT203013 NZ_CP075118:c3596264-3595932 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References