221552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3170218..3170632 Replicon chromosome
Accession NZ_CP085801
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailord

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF52_RS15760 Protein ID WP_000994230.1
Coordinates 3170375..3170632 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3170218..3170550 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF52_RS15720 3165479..3165976 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF52_RS15725 3166739..3167309 - 571 Protein_3070 integrase core domain-containing protein -
LJF52_RS15730 3167230..3167439 - 210 WP_001676010.1 hypothetical protein -
LJF52_RS15735 3167492..3167806 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF52_RS15740 3167873..3168151 - 279 WP_012543321.1 hypothetical protein -
LJF52_RS15745 3168468..3168935 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF52_RS15750 3168932..3169249 - 318 WP_001751277.1 hypothetical protein -
LJF52_RS15755 3169807..3170040 - 234 WP_124084119.1 hypothetical protein -
- 3170218..3170550 - 333 - - Antitoxin
LJF52_RS15760 3170375..3170632 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF52_RS15765 3170698..3171144 - 447 WP_000171102.1 hypothetical protein -
LJF52_RS15770 3171141..3174515 - 3375 Protein_3079 RHS domain-containing protein -
LJF52_RS15775 3174515..3175021 - 507 Protein_3080 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3157583..3174437 16854
flank IS/Tn - - 3166739..3167017 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221552 WP_000994230.1 NZ_CP085801:3170375-3170632 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221552 NZ_CP117481:1970494-1970596 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 333 bp

>AT221552 NZ_CP085801:c3170550-3170218 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References