221836

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1548208..1548622 Replicon chromosome
Accession NZ_CP085814
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF38_RS07250 Protein ID WP_000994230.1
Coordinates 1548208..1548465 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1548290..1548622 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF38_RS07235 1543819..1544325 + 507 Protein_1397 phage late control D family protein -
LJF38_RS07240 1544325..1547699 + 3375 Protein_1398 RHS domain-containing protein -
LJF38_RS07245 1547696..1548142 + 447 WP_000171102.1 hypothetical protein -
LJF38_RS07250 1548208..1548465 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 1548290..1548622 + 333 - - Antitoxin
LJF38_RS07255 1548800..1549033 + 234 WP_124084119.1 hypothetical protein -
LJF38_RS07260 1549591..1549908 + 318 WP_001751277.1 hypothetical protein -
LJF38_RS07265 1549905..1550372 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF38_RS07270 1550689..1550967 + 279 WP_012543321.1 hypothetical protein -
LJF38_RS07275 1551034..1551348 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF38_RS07280 1551401..1551610 + 210 WP_001676010.1 hypothetical protein -
LJF38_RS07285 1551531..1552101 + 571 Protein_1407 integrase core domain-containing protein -
LJF38_RS07290 1552864..1553361 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1542904..1561995 19091
flank IS/Tn - - 1551823..1552101 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221836 WP_000994230.1 NZ_CP085814:c1548465-1548208 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221836 NZ_CP117606:c261094-260876 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 333 bp

>AT221836 NZ_CP085814:1548290-1548622 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References