207393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3805771..3806203 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag KTP12_RS19045 Protein ID WP_000994224.1
Coordinates 3805928..3806203 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3805771..3806193 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP12_RS19015 3801989..3802726 - 738 WP_001535430.1 pili assembly chaperone SafB -
KTP12_RS19020 3802810..3803322 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
KTP12_RS19025 3804072..3804776 - 705 Protein_3723 integrase core domain-containing protein -
KTP12_RS19030 3804829..3805077 + 249 WP_001738030.1 SymE family type I addiction module toxin -
KTP12_RS19035 3805179..3805487 - 309 WP_010988969.1 hypothetical protein -
KTP12_RS19040 3805570..3805743 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3805771..3806193 - 423 - - Antitoxin
KTP12_RS19045 3805928..3806203 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
KTP12_RS19050 3806256..3806693 - 438 WP_022742610.1 immunity 26/phosphotriesterase HocA family protein -
KTP12_RS19055 3807256..3807702 - 447 WP_000935097.1 protein SciX -
KTP12_RS19060 3807696..3809700 - 2005 Protein_3730 polymorphic toxin type 47 domain-containing protein -
KTP12_RS19065 3809719..3810165 - 447 WP_000375832.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3794919..3808031 13112
flank IS/Tn - - 3804072..3804353 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T207393 WP_000994224.1 NZ_CP077668:3805928-3806203 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T207393 NZ_CP102975:c820728-820540 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACATTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 423 bp

>AT207393 NZ_CP077668:c3806193-3805771 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References